Prof. Tiziano Tuccinardi
- Full Professor at the Department of Pharmacy, University of Pisa.
Adjunct Associate Professor at the Department of Biology, College of Science and Technology, Temple University. Philadelphia, PA, USA.
Adjunct Assistant Professor at the Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University. Philadelphia, PA, USA.
Visiting Researcher (with Prof. Anne Baranger), Department of Chemistry, University of Illinois at Urbana-Champaign. Urbana, IL, USA.
Assistant Professor at the Department of Pharmacy, University of Pisa.
Post-doctorate in the Molecular Modeling & Virtual Screening Laboratory at the University of Pisa with Professor Adriano Martinelli.
AWARDS
- October 2022 = Member of the 1% top scientists for the Medicinal & Biomolecular Chemistry field (ranked 642 out of 94672 scientists); as reported by: Ioannidis, John P.A. “September 2022 data-update for “Updated science-wide author databases of standardized citation indicators.”” 2022, Mendeley Data, V5, doi: 10.17632/btchxktzyw.5
- June 2021 = ESMEC Alumni Award (First edition). European award given to an outstanding European researcher in the field of Medicinal Chemistry who has participated in one of the forty editions of the European School of Medicinal Chemistry (ESMEC) either as an oral or poster presenter.
- December 2020 = Member of the 2% top scientists for the Medicinal & Biomolecular Chemistry field (ranked 871 out of 80622 scientists); as reported by: Ioannidis JPA, Boyack KW, Baas J. “Updated science-wide author databases of standardized citation indicators.” PLoS Biol. 2020 18(10):e3000918. doi: 10.1371/journal.pbio.3000918.
- September 2019 = Global Peer Review Awards, for placing in the top 1% of reviewers in Cross-Field and in Chemistry on Publons global reviewer database (from Publons, Clarivate Analytics).
- June 2019 = Artificial Intelligence Molecular Screen (AIMS) Award 2019 for the Project ID: A19-181, “Identification of new reversible MAGL inhibitors” (from Atomwise Inc., San Francisco, CA 94103.
- December 2017 = Individual annual funding for academic research activities, top 25% in the associate professor national ranking (from Italian Government).
- April 2013 = Young Scientist Award for the high publication rating in the 2008-2012 period (from University of Pisa).
- November 2011 = Young Scientist Award for the high publication rating in the 2006-2010 period (from University of Pisa).
- July 2010 = Farmindustria 2010 Award for the best young Italian medicinal chemist (from Farmindustria and Pharmaceutical Chemistry Division of the Italian Chemical society).
RECOGNITIONS
- Director of the PhD program “Science of Drug and Bioactive Substances”, Department of Pharmacy, University of Pisa.
- Member of the PhD program “Genomic and experimental medicine (GEM)”, Scuola Superiore Meridionale (SSM).
- Member of University Scientific Committee (chemistry sector), University of Pisa.
- Director of the “Pharmaceutical Chemistry and Technology” MD (long cycle) programme, University of Pisa (click here).
- Member of the Marine pharmacology center of the University of Pisa
- Scientific Advisory Board Member of the Bio Future Medicine (BFM) startup.
- Director of the “Computer-Aided Drug Design” International Summer School (I-VIII CADDISS edition), Pisa, Italy.
- Member of the NutraFood research center of the University of Pisa
- Member of the Health Technology Assessment center of the University of Pisa
- Member of the PhD program “Science of Drug and Bioactive Substances”, Department of Pharmacy, University of Pisa.
- Scientific Advisory Board Member of the EWDD European workshop in Drug Design (IX-XII edition) Siena, Italy.
- Opinion leader guest at the international master “Design a Contamination Control Strategy for Aseptic/Sterile Products and Processes” November 26-28, 2019, Rome (Italy).
- Chairman of the 4th Satellite Meeting on Carbonic Anhydrases (Parma, Italy, November, 14-17 2019).
- Chairman of the XII EWDD European workshop in Drug Design (Siena, May, 19-24 2019).
- Member of University Scientific Committee (chemistry sector), University of Pisa.
- Co-chairman of the “Molecular modelling studies” session of the 3nd International Bau Drug Design Congress (Istanbul, Turkey, October 1-3 2015).
MAIN EDITORIAL DUTIES
- Editor in Chief of Mini-Reviews in Medicinal Chemistry published by Bentham.
- Editorial Board Member of Plos One published by PLOS.
- Editorial Board Member of Bioorganic Chemistry published by Elsevier.
- Editorial Board Member of Molecules (Medicinal Chemistry section) published by MDPI.
- Editorial Board Member of the Journal of Enzyme Inhibition & Medicinal Chemistry published by Taylor & Francis.
LAST PUBLICATIONS (2023-2022) – others see C.V.
2023
213 Di Stefano M, Galati S, Piazza L, Granchi C, Mancini S, Fratini F, Macchia M, Poli G, Tuccinardi T. VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules. J Chem Inf Model. 2023 doi: 10.1021/acs.jcim.3c00692. Epub ahead of print.
212 Saorin G, Mauceri M, Cavarzerani E, Caligiuri I, Bononi G, Granchi C, Bartoletti M, Perin T, Tuccinardi T, Canzonieri V, Adeel M, Rizzolio F. Enhanced Activity of a Pluronic F127 Formulated Pin1 Inhibitor for Ovarian Cancer Therapy. J. Drug Deliv. Sci. Technol. 2023, 87, 104718.
211 Galati S, Di Stefano M, Macchia M, Poli G, Tuccinardi T. MolBook UNIPI – create, manage, analyze and share your chemical data for free. J Chem Inf. 2023, 63(13):3977-3982.
210 Poli G, Demontis GC, Sodi A, Saba A, Rizzo S, Macchia M, Tuccinardi T. An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65. J Enzyme Inhib Med Chem. 2023, 38(1):2162047.
209 De Logu F, Maglie R, Titiz M, Poli G, Landini L, Marini M, Souza Monteiro de Araujo D, De Siena G, Montini M, Cabrini DA, Otuki MF, Pawloski PL, Antiga E, Tuccinardi T, Calixto JB, Geppetti P, Nassini R, André E. miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4. J Invest Dermatol. 2023, 143(1):142-153.e10.
2022
208 Carradori S, Fantacuzzi M, Ammazzalorso A, Angeli A, De Filippis B, Galati S, Petzer A, Petzer JP, Poli G, Tuccinardi T, Agamennone M, Supuran CT. Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases? Molecules. 2022, 27(22):7816.
207 Bononi G, Masoni S, Di Bussolo V, Tuccinardi T, Granchi C, Minutolo F. Historical perspective of tumor glycolysis: A century with Otto Warburg. Semin Cancer Biol. 2022, 86(Pt 2):325-333.
206 Bononi G, Citi V, Lapillo M, Martelli A, Poli G, Tuccinardi T, Granchi C, Testai L, Calderone V, Minutolo F. Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives. Molecules. 2022, 27(19):6535.
205 Sainas S, Giorgis M, Circosta P, Poli G, Alberti M, Passoni A, Gaidano V, Pippione AC, Vitale N, Bonanni D, Rolando B, Cignetti A, Ramondetti C, Lanno A, Ferraris DM, Canepa B, Buccinnà B, Piccinini M, Rizzi M, Saglio G, Al-Karadaghi S, Boschi D, Miggiano R, Tuccinardi T, Lolli ML. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety. J Med Chem. 2022, 65(19):12701-12724.
204 Di Stefano M, Galati S, Ortore G, Caligiuri I, Rizzolio F, Ceni C, Bertini S, Bononi G, Granchi C, Macchia M, Poli G, Tuccinardi T. Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors. Int J Mol Sci. 2022, 23(18):10653.
203 Balestri F, Poli G, Piazza L, Cappiello M, Moschini R, Signore G, Tuccinardi T, Mura U, Del Corso A. Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches. Biology. 2022, 11(9):1324.
202 Ceni C, Benko MJ, Mohamed KA, Poli G, Di Stefano M, Tuccinardi T, Digiacomo M, Valoti M, Laprairie RB, Macchia M, Bertini S. Novel Potent and Selective Agonists of the GPR55 Receptor Based on the 3-Benzylquinolin-2(1H)-One Scaffold. Pharmaceuticals. 2022, 15(7):768.
201 Mancini S, Fratini F, Provera I, Dovicchi J, Tuccinardi T, Minieri S, Papini RA, Forzan M, Paci G. Growth performances, chemical composition, and microbiological loads of mealworm reared with brewery spent grains and bread leftovers. Ital J An Sc. 2022, 21(1):1419-1429.
200 Galati S, Sainas S, Giorgis M, Boschi D, Lolli ML, Ortore G, Poli G, Tuccinardi T. Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study. Molecules. 2022, 27(12):3660.
199 Poli G, Barravecchia I, Demontis GC, Sodi A, Saba A, Rizzo S, Macchia M, Tuccinardi T. Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations. J Enzyme Inhib Med Chem. 2022, 37(1):1765-1772.
198 Bononi G, Di Stefano M, Poli G, Ortore G, Meier P, Masetto F, Caligiuri I, Rizzolio F, Macchia M, Chicca A, Avan A, Giovannetti E, Vagaggini C, Brai A, Dreassi E, Valoti M, Minutolo F, Granchi C, Gertsch J, Tuccinardi T. Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. J Med Chem. 2022, 65(10):7118-7140.
197 Bononi G, Flori L, Citi V, Acciai C, Nocilla V, Martelli A, Poli G, Tuccinardi T, Granchi C, Testai L, Calderone V, Minutolo F. New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds. Pharmaceuticals (Basel). 2022, 15(3):339.
196 Cazzaniga G, Mori M, Meneghetti F, Chiarelli LR, Stelitano G, Caligiuri I, Rizzolio F, Ciceri S, Poli G, Staver D, Ortore G, Tuccinardi T, Villa S. Virtual screening and crystallographic studies reveal an unexpected γ-lactone derivative active against MptpB as a potential antitubercular agent. Eur J Med Chem. 2022, 234:114235.
195 Galati S, Di Stefano M, Martinelli E, Macchia M, Martinelli A, Poli G, Tuccinardi T. VenomPred: A Machine Learning Based Platform for Molecular Toxicity Predictions. Int J Mol Sci. 2022, 23(4):2105.
194 Ibrahim AIM, Batlle E, Sneha S, Jiménez R, Pequerul R, Parés X, Rüngeler T, Jha V, Tuccinardi T, Sadiq M, Frame F, Maitland NJ, Farrés J, Pors K. Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer. J Med Chem. 2022, 65(5):3833-3848.
193 Ortore G, Poli G, Martinelli A, Tuccinardi T, Rizzolio F, Caligiuri I. From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives. Med Chem. 2022, 18(2):249-259.
192 Abdalla AN, Di Stefano M, Poli G, Tuccinardi T, Bader A, Vassallo A, Abdallah ME, El-Readi MZ, Refaat B, Algarni AS, Ahmad R, Alkahtani HM, Abdel-Aziz AA-, El-Azab AS, Alqathama A. Co-inhibition of p-gp and hsp90 by an isatin-derived compound contributes to the increase of the chemosensitivity of mcf7/adr-resistant cells to doxorubicin. Molecules 2022, 27(1):90.
191 Adeel M, Saorin G, Boccalon G, Sfriso AA, Parisi S, Moro I, Palazzolo S, Caligiuri I, Granchi C, Corona G, Cemazar M, Canzonieri V, Tuccinardi T, Rizzolio F. A Carrier Free Delivery System of a Monoacylglycerol Lipase Hydrophobic Inhibitor. Int J Pharm. 2022, 613:121374.
190 Poli G, Di Stefano M, Estevez JA, Minutolo F, Granchi C, Giordano A, Parisi S, Mauceri M, Canzonieri V, Macchia M, Caligiuri I, Tuccinardi T, Rizzolio F. New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy. J Enzyme Inhib Med Chem. 2022, 37(1):145-150.